This film American Artist: Earthseed, features The Monophobic Response by American Artist, showcasing the exploration of technology, society, and speculative futures. Rooted in the legacies of Octavia E. Butler, an American science fiction writer, and African-diasporic communities in California, American Artist's work critically engages with technology, science fiction, and their lineage within America’s Second Great Migration. Their LACMA Art + Technology Lab project The Monophobic Response reimagines the 1936 GALCIT Rocket Motor Test through Butler's Earthseed community while their 2022 exhibition Shaper of God at RedCat draws from Butler’s life in Los Angeles to explore cycles of history and dystopian futures. Artist’s 2024 exhibition, The Monophobic Response, at LACMA coincides with this film, presenting original footage from the Mojave Desert, where the artist staged a rocket engine test fire, weaving together speculative fiction and real-world political concerns.

American Artist is a recipient of the 2021 LACMA Art + Technology Lab grant. Inspired by the spirit of LACMA's original Art and Technology program (1967–71), which paired artists with technology companies in Southern California, the LACMA Art + Technology Lab supports artist experiments with emerging technology. The LACMA Art + Technology Lab is presented by Hyundai Motor.

American Artist makes thought experiments that mine the history of technology, race, and knowledge production, beginning with their legal name change in 2013. Their artwork primarily takes the form of sculpture, software, and video. Artist is a recipient of the 2024 New York Artadia Award and a Trellis Art Fund grantee. They are a former resident of Smack Mellon, Red Bull Arts Detroit, Abrons Art Center, Recess, EYEBEAM, Pioneer Works, and the Whitney Museum Independent Study Program. They have exhibited at the Solomon R. Guggenheim Museum, Whitney Museum of American Art, The Museum of Modern Art, the Studio Museum in Harlem, the Museum of Contemporary Art Chicago, Kunsthalle Basel, Switzerland, and Nam June Paik Art Center, Seoul. Their work has been featured in The New York Times, Cultured, Artforum, and Art in America. Artist is a former co-director of the School for Poetic Computation and a faculty at Yale University.